Dog Owners

Canine Joint Disease

Canine Joint Disease

Arthritis is caused by an abnormal load on a normal joint, or a normal load on an abnormal joint. Canine joint disease can be characterized by a number of factors.


These can include:

  • Progressive cartilage deterioration in the synovial joint
  • Loss of articular cartilage and its components
  • Changes in the normal bone architecture
  • Loss of joint mobility and joint space
  • Inflammation of synovial membrane with associated pain



Cartilage Injury

Cartilage Injury1. When proteoglycan becomes degraded and synthesis decreases, cartilage loses thickness and elasticity, resulting in an inability to bear loads and impaired nutrient-waste exchange.


Cartilage Damage

Cartilage Damage2. Debris and enzymes spill into synovial fluid, splitting long-chained hyaluronate molecules into short segments. Lubrication and ability to block inflammatory cells are lost. Debris-tainted synovial fluid further loses ability to facilitate nutrient-waste exchange with cartilage.


Catabolic Enzymes

Catabolic Enzymes3. When damage spreads to the synovial membrane, synoviocytes secrete more inflammatory mediators and catabolic enzymes. Inflammatory cells stream into the joint, and the first signs of pain appear.

Product Information
Product Information
Did You Know ...
Did You Know?

About 20% of all adult dogs in the U.S. suffer from canine arthritis.

Adequan® Canine (polysulfated glycosaminoglycan or PSGAG) should not be used in dogs who are hypersensitive to PSGAG or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Possible side effects (pain at injection site, diarrhea and abnormal bleeding) were mild, transient and self-limiting. Safety studies of PSGAG in breeding, pregnant or lactating dogs have not been conducted. Click here for full product information.

Interwoven VisualPreview: //

New Form Import Edit Upload Submit