Adequan® Canine (polysulfated glycosaminoglycan) is administered two times a week for four weeks. The drug is injected intramuscularly to ensure it reaches the critical parts of the joint. It goes to work in the joint in about two hours and stays in the joint for about three days. With Adequan® Canine you should see signs of improvement within four weeks. Your dog may begin to act like the playful, active dog you remember.